Product IQ

The Internet and online commerce has created tremendous advantages for both the global consumer and vendor. Yet businesses and consumers, who enjoy the benefits of quick and easy sales as vendors enjoy concomitant access to a world of potential customers. Yet this is the exact same rationale for illicit vendors who peddle counterfeit products and services online.

The dangers associated with these products of course are legion. Fake foods, medicines, electrical chords, baby formula, brake pads, aircraft parts, all have been found in use purchased through "legitimate" channels online. Further, illicit payments for sales and use of these products is also critical intelligence. Hence, it is critical that business, governments, and consumers have up-to-date information on genuine products, any warnings of fakes, and any illegal payments to induce their use..

S-3 has been able to create Product IQ assessments, ie, the perceptions, complaints, potential illicit vending, and other avenues relevant to the legitimate seller and buyer, and to promote useful expansions of buyer-seller cooperation and communication. Some of our work in this area includes:

Xu Q, Li J, Cai M, Mackey TK. Use of Machine Learning to Detect Wildlife Product Promotion and Sales on Twitter. Front. Big Data. 2019;


Li J, Xu Q, Shah N, Mackey TK. Detection and Characterization of Illicit Digital Drug Dealers on Instagram using Machine Learning. J Med Internet Res. 2019; 21(6):e13803.


Mackey TK, Kalyanam J, Klugman J, Kuzmenko E, Gupta R. Solution to Detect, Classify, and Report Illicit Online Marketing and Sales of Controlled Substances via Twitter:  Using Machine Learning and Web Forensics to Combat Digital Opioid Access. J Med Internet Res. 2018;20(4):e10029.


Mackey TK, Kalyanam J. Detection of Illicit Online Sales of Fentanyls via Twitter. F1000. 2017;6:1937


Guerra C, Mackey TK. U.S. Criminal and Civil Prosecutions Associated with Illicit Online Pharmacies: Legal Analysis and Global Implications. Medicines Access @ Point of Care. 2017;1(1):e104-e118.


Mackey TK, Kalyanam J, Katsuki T, Lanckriet G. Twitter-Based Detection of Illegal Online Sale of Prescription Opioid. Am J. Pub Health. 2017;107:1910-1915.


Tringale K, Marshall D, Mackey TK, Connor M, Murphy J, Hattangadi-Gluth J. Types and Distribution of Payments from Industry to Physicians in 2015. JAMA. 2017;317(17):1774-1784.


Mackey TK, Nayyar G. A Review of Existing and Emerging Digital Technologies to Combat the Global Fake Medicines Trade. Expert Opin Drug Saf. 2017;16(5):587-602. [named as a top Blockchain academic paper during the Blockchain Connect Conference Academic 2019, SV Insight] 


Cuomo RE, Mackey TK. The Availability of Essential Cancer Medication: An Analysis of National Formularies. J Cancer Policy. 2017;12:49-54.


Marshall D, Moy B, Jackson M, Mackey TK, Hattangadi-Gluth J. Distribution and Patterns of Industry-related Payments to Oncologists in 2014. J Natl Cancer Inst. 2016;108(12).


Mackey TK, Liang BA. After Amarin: What Will the Future Hold for Off-Label Promotion Regulation? Mayo Clin Proc. 2016;91(6):701-706.


Mackey TK. Digital Direct-to-Consumer Advertising: A Perfect Storm of Rapid Evolution and Stagnant Regulation; Comment on “Trouble Spots in Online Direct-to-Consumer Prescription Drug Promotion: A Content Analysis of FDA Warning Letters”. Int J Health Policy Manag. 2016;5(4):271-274.


Anderson A, Mackey TK, Attaran A, Liang BA. Mapping of Health Communication and Education Strategies Addressing the Public Health Dangers of Illicit Online Pharmacies. J. Health Commun. 2016;21(4):397-407.


Mackey TK, Miner A, Cuomo RE. Exploring the e-Cigarette e-Commerce Marketplace: Identifying Internet e-Cigarette Marketing Characteristics and Regulatory Gaps. Drug Alcohol Depend. 2015; 156:97-103.


Mackey TK, Cuomo RE, Liang BA. The Rise of Digital Direct-to-Consumer Advertising?: Comparison of Direct-to-Consumer Advertising Expenditure Trends from Publicly Available Data Sources and Global Policy Implications. BMC Health Serv Res. 2015;15:236.


Mackey TK, Liang BA. Global Reach of Direct-to-Consumer Advertising Using Social Media for Illicit Online Drug Sales. J Med Internet Res. 2013;15(5):e105.


Lovett KM, Mackey TK, Liang BA. Evaluating the evidence: direct-to-consumer screening tests advertised online. J Med Screen. 2012;19:141–153.


Lovett KM, Liang BA, Mackey TK. Risks of Online Direct-to-Consumer Tumor Markers for Cancer Screening. J Clin. Onc. 2012;30(13):1411-1414. 


Lovett KM, Liang BA, Mackey TK. Online Direct-to-Consumer Access to Insulin: Patient Safety Considerations and Reform. J Diab Sci Tech. 2012;6(6):1503-1506.


Mackey TK, Liang BA, Lovett KM. Waking Up to the Risks of Online Direct-to-Consumer Advertising of Sleep Apnea Screening Tests. J Clin Sleep Med. 2012;8(1):5-6.


Liang BA, Mackey TK. Consent Contraindicated? In Reply. Science. 2010;328(5974):45.


Liang BA, Mackey TK. Reforming Off-Label Promotion to Enhance Orphan Disease Treatment.          Science. 2010;327(5963):273-274.


© 2019 S-3 Research, LLC.